BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

Study of rationalism in Urdu literature.

On Sikh ethics; includes brief biographies of Sikh religious leaders.

"There are no paradoxes in mathematics," says Kurt Gödel. Moreover, Gödel seems to be right on this count. That is, there are no paradoxes, in the strict sense of the word, internal to the known and available body of mathematical knowledge. But while there are no paradoxes in mathematics, there certainly is an embarrassing bag of difficulties when we come to the application of mathematical concepts to the physical world. Of these, perhaps the most unruly offenders of all are the (...) problems proposed about 2500 years ago by Zeno and which, in modern idiom, have to do with the proper mathematical treatment of phenomena involving change and motion, and the physical meaning—if any—which may be assigned to convergent infinite series. At each stage in the growth of mathematical knowledge since their formulation Zeno's paradoxes have been the subject of some alleged resolution. Now Grünbaum contributes to this tradition, and it must be said that he makes a strong case. The weapons in the intellectual arsenal which Grünbaum brings to bear upon Zeno include such sophisticated devices as measure theory, but the weak link in the argument is in the first chapter where the author presents his somewhat psychologistic theory of temporal becoming. Grünbaum has a great many interesting things to say in later chapters about infinite processes, quantum mechanics, and Hilary Putnam. This is a first-rate contribution to the philosophy of physics.—H. P. K. (shrink)

Context: Many recent research areas such as human cognition and quantum physics call the observer-independence of traditional science into question. Also, there is a growing need for self-reflexivity in science, i.e., a science that reflects on its own outcomes and products. Problem: We introduce the concept of second-order science that is based on the operation of re-entry. Our goal is to provide an overview of this largely unexplored science domain and of potential approaches in second-order fields. Method: We provide the (...) necessary conceptual groundwork for explorations in second-order science, in which we discuss the differences between first- and second-order science and where we present a roadmap for second-order science. The article operates mainly with conceptual differentiations such as the separation between three seemingly identical concepts such as Science II, Science 2.0 and second-order science. Results: Compared with first-order science, the potential of second-order science lies in 1. higher levels of novelty and innovations, 2. higher levels of robustness and 3. wider integration as well as higher generality. As first-order science advances, second-order science, with re-entry as its basic operation, provides three vital functions for first-order science, namely a rich source of novelty and innovation, the necessary quality control and greater integration and generality. Implications: Second-order science should be viewed as a major expansion of traditional scientific fields and as a scientific breakthrough towards a new wave of innovative research. Constructivist content: Second-order science has strong ties with radical constructivism, which can be qualified as the most important root/origin of second-order science. Moreover, it will be argued that a new form of cybernetics is needed to cope with the new problems and challenges of second-order science. (shrink)

DaB fUr die Entwicklung der Phanomenologie Husserls nicht zuletzt auch,wissenschaftstheoretische' Motive ausschlaggebend waren, ist hinreichend bekannt. Umso mehr verwundert es, daB die Husserl-Rezeption sich diese Motive nur selten zueigen gemacht hat. Zwar sind in einer Reihe von Einzel­ wissenschaften, wie in der Literaturwissenschaft, der Sozialwissenschaft und besonders auch der Psychologie, phanomenologische Motive wirksam gewor­ den. Versuche einer ausdriicklichen wissenschaftskritischen Anwendung der Husserlschen Philosophie auf einzelwissenschaftliehe Theorien jedoch, wie sie z.B. Alfred Schiitz in seinem friihen Werk zur phanomenologischen Grundlegung der "verstehenden (...) Soziologie"l ansatzweise unternommen hat, sind rar. Freilich ging auch Husserl hier nieht eben mit gutem Beispiel voran. Auch er selbst hat seine wissenschaftstheoretische Programmatik nirgends einer ernsthaften Bewahrungsprobe unterzogen. Die vorliegende Untersuchung will diese Frage einer wissenschaftstheore­ tischen Anwendbarkeit der transzendentalen Phiinomenologie paradigmatisch im Hinblick auf die Problemstellungen der Geschiehtswissenschaft iiberprii­ fen. Was also kann die Phanomenologie fUr die Historik leisten? DaB sieh fiir eine solche Absieht gerade die geschichtstheoretischen Perspektiven in Hus­ serls Werk anbieten, hat vor allem zwei Griinde. (shrink)

Context: The journal Constructivist Foundations celebrates ten years of publishing articles on constructivist approaches, in particular radical constructivism. Problem: In order to preserve the sustainability of radical constructivism and regain its appeal to new generations of researchers, we set up a new course of action for and with the radical constructivist community to study its innovative potential. This new avenue is “second-order science.” Method: We specify two motivations of second-order science, i.e., the inclusion of the observer, and self-reflexivity that allows (...) second-order science to operate on the products of normal or first-order science. Also, we present a short overview of the contributions that we have collected for this inaugural issue on second-order science. Results: These six initial contributions demonstrate the potential of the new set of approaches to second-order science across several disciplines. Implications: Second-order science is believed to be a cogent concept in the evolution of science, leading to a new wave of innovations, novel experiments and a much closer relationship with current research in the cognitive neurosciences in particular, and with evolutionary and complexity theories in general. (shrink)

The aim of this dissertation is to present a systematic account of F. H. Bradley's philosophy in so far as it is relevant to an understanding of his conception of the nature and criterion of truth. I argue that, for Bradley, the nature of truth is the identity of thought with reality given in immediate experience. There is no absolute separation between thought and its object. Bradley therefore rejects both the correspondence theory and epistemological realism. Thought is not just a (...) mirror which reflects an independently existing reality. ;Concerning the criterion of truth, I argue that his criterion for our ordinary and scientific beliefs is practice, and the criterion for philosophical positions is a kind of coherence based on the doctrine of relative truth. For Bradley, some positions are truer than others, and the best philosophy is a comprehensive system which contains the truth of all different positions. ;Bradley does not accept the coherence theory of justification as it is understood today, since it is based on the standard account of negation and the doctrine of absolute truth. Bradley has a different approach to negation and inconsistency, according to which there are no absolutely inconsistent beliefs. Further, he insists that truth is not absolute but "relative," a matter of degree. All philosophical positions contain some truth, and none is completely false. The truth in philosophy is a position which accounts for the whole of reality and includes all apparently inconsistent positions within it. ;I explain Bradley's place in the history of philosophy and show his connections with the British empiricist tradition. I believe one of Bradley's central concerns is to explain the nature and criterion of truth in philosophy within the constraints of empiricism. I also contrast Bradley's positions on important issues with those of philosophers in the Anglo-American analytic tradition, such as Russell, Moore, Ayer, Tarski, Quine, Churchland, Lehrer and Campbell. I argue that most recent commentators on Bradley overlook the importance of understanding his philosophy as a system constructed according to the doctrine of relative truth. (shrink)

The concept of experience has been central to European philosophy since Descartes. He was the first to use experience to distinguish between two kinds of substance, mental and material, on the basis of the fact that one kind of substance is extended but does not think, while the other kind thinks, doubts, wills, imagines and feels, but is not extended. Other philosophers, such as Hobbes, Locke and Hume, made the concept of experience the basis of their analysis of knowledge. These (...) ideas have become part of common sense, and provide the background for a range of philosophical problems from Descartes’ time to the present. While the concept of experience is important for philosophy, philosophers do not all have the same understanding of the nature of experience. (shrink)

Translation and interpretation of selected Hadith on Islamic ethics and coduct.

Context: Although second-order cybernetics was proposed as a new way of cybernetic investigations around 1970, its general status and its modus operandi are still far from obvious. Problem: We want to provide a new perspective on the scope and the currently available potential of second-order cybernetics within today’s science landscapes. Method: We invited a group of scholars who have produced foundational work on second-order cybernetics in recent years, and organized an open call for new approaches to second-order cybernetics. The accepted (...) contributions are discussed and mapped. We also investigate the relations between second-order cybernetics and second-order science. Results: We present a coherent outlook on the scope of second-order cybernetics today, identify a general methodology of science and show that second-order cybernetics can be used in a large number of disciplines that go well beyond purely scientific domains. These results are based on a new epistemic mode “from within,” which can be traced back directly to von Foerster. We also arrived at the conclusion that from its early years onwards second-order cybernetics was developed in two different ways, so that second-order cybernetics and second-order science operate in different domains. Implications: Both the coherent perspective of the scope of second-order cybernetics with a new five-part agenda and the outline for a general methodology of science based on a new epistemic mode that was created within and for second-order cybernetics demonstrate the growing importance of reflexivity in science, which, so far, has not been widely recognized. (shrink)

Islamic ethics in the light of Qurʼanic teaching and Hadith; Customs and practices.

In the last few years there has been a revival of interest in F.H. Bradley and particularly the account of judgment contained in The Principles of Logic. Many of those who discuss Bradley’s theory of judgment mistakenly assume that it can best be seen as a linguistic account. They insist that what Bradley says can be understood as an account of the meaning and reference of words or sentences. In this paper I will argue that Bradley’s theory of judgment is (...) essentially a psychological theory. Judgment is the union of part of the content of an image or other mental particular with our immediate experience. There is no evidence for the linguisitc interpretation and its defenders cannot make sense of Bradley’s discussion of a number of technical points, particularly his criticism of the view that judgment is the synthesis of ideas, and his comments on the idea of “this.” I will also argue that Bradley’s account of judgment cannot be separated from his later metaphysics and is essentially Hegelian in character. To explain Bradley’s theory I will begin where he does, with an examination of the nature of ideas. (shrink)

Open peer commentary on the article “Luhmann and the Constructivist Heritage: A Critical Reflection” by Armin Scholl. Upshot: The comment starts with Buchinger’s assessment that Luhmann’s contribution to constructivism is original and inspiring, but raises more questions than answers. In three variations, the comment tries to show that Luhmann can indeed be viewed as a big question-generator and that his heritage for radical constructivism may lie in the original and inspiring effects these new and additional questions can produce.

Purpose: Several accounts like Ernst von Glasersfeld's Who Conceives of Society? (2008) locate empirical research in the social sciences and radical constructivism in almost parallel universes. The main purpose of this paper is to argue for more inter-active relations and to stress the importance of establishing weak, medium and strong ties between radical constructivism and empirical social research in general. Findings: The article shows that that weak, medium and strong ties between radical constructivism and empirical research in the social sciences (...) can be established. Moreover, these weak, medium and strong ties play a crucial role for increasing and maintaining the relevance of radical constructivism within the social sciences and for contributing to the viability of radical constructivism in the long run. Implications: The most important consequence for radical constructivism lies in a new research agenda. In the course of this article weak, medium and strong ties to empirical research have been specified specifically and exclusively for the social sciences. But these specific links cannot be simply generalized or transferred to other disciplinary fields outside the social sciences. Since interactive links between radical constructivism and empirical research are currently missing in practically all disciplines, these weak, medium and strong links, as a new RC-agenda, have to be developed separately for each major scientific research arena. (shrink)

Purpose: Josef Mitterer's essays are considered to be important philosophical advancements of radical constructivism. The main purposes of this paper are, on the one hand, to structure the RC landscape and, on the other hand, to investigate the relations of Mitterer's work to radical constructivism in particular and to philosophy in general. Findings: In this short essay focusing on Mitterer's Das Jenseits der Philosophie, I would like to stress two major points. First, Mitterer's book should be considered as one of (...) several contemporary variants of a radical critique of the semantic turn in the philosophy of science that has taken place since the mid-thirties with the works of Rudolf Carnap, Carl G. Hempel, Hilary Putnam, Alfred Tarski and others. Second, it is by no means clear how to determine the relevance of the new semantic critique for the present and future cognitive status of radical constructivism. The degree of relevance depends crucially on the use of the term "radical constructivism." If radical constructivism, as I will argue, is seen as an umbrella term for a group of empirical research programs, then, by sheer necessity, the relevance can be marginal only. If, however, radical constructivism is viewed as a special form of philosophy of language and/or as a new epistemology, then the importance of Josef Mitterer's approach must be judged within the context of available functional alternatives. Implications: An immediate consequence of this article lies in a renewed emphasis on advancing an empirical research agenda for radical constructivism and in an effective downsizing of radical constructivism as a philosophical perspective. (shrink)

Open peer commentary on the target article “From Objects to Processes: A Proposal to Rewrite Radical Constructivism” by Siegfried J. Schmidt. Upshot: The subtitle of “An Austrian Contribution” emphasizes a basic distinction between German and Austrian traditions in the philosophy of fields of science. In S. J. Schmidt’s genuinely German way of writing, one can observe a high emphasis on terminology and a specific arena of heavy philosophical problems that have to be solved in a strictly philosophical manner, whereas the (...) Austrian tradition places its importance on scientific progress, especially in the natural sciences, and on the clarifying, mediating, and self-reflecting role of philosophy within the overall context of scientific evolution. (shrink)

Open peer commentary on the target article “Who Conceives of Society?” by Ernst von Glasersfeld. Excerpt: I will make the point that radical constructivism von Glasersfeld style unnecessarily plays only a passive or an inactive role. Quite obviously, I want to demonstrate that there is life for radical constructivism outside its seemingly irrelevant function in empirical social research and that it is possible to develop radical constructivism in designs with tangible consequences and effects for the cognitive routines in the social (...) sciences. In short, it is conceivable, despite “Who Conceives of Society?”, that radical constructivism matters. (shrink)

Context: The main problem is the rather marginal status of radical constructivism within its core domains of brain research, cognition and learning. Problem: The basic goal is to provide a short history of radical constructivism and its institutionalization processes. Additionally, the article specifies critical conditions that should be met in order for radical constructivism to become a mainstream endeavor. Method: The main methods used are those of comparative historical research. Results: The main results lie in the specification of missing elements (...) that have blocked radical constructivism becoming a mainstream endeavor. Implications: The paper might serve as a common reference for necessary steps to be taken over the following years in order to move radical constructivism out of its current weak position. (shrink)

Purpose: The article pursues three aims. First, it intends to differentiate between two different approaches for knowledge studies, namely an empirical and a normative mode. In a second move, two different epistemologies in the work of Ernst von Glasersfeld will be introduced under the labels of “Epistemology I” and “Epistemology II.” Epistemology I relates to empirical research, Epistemology II is normative in nature. Third, the article makes the point that while Ernst von Glasersfeld’s Epistemology II has already been presented in (...) a finite and mature form, his empirical analysis of cognitive processes still provides a rich pool of tools and designs that should be further developed and advanced in the years and decades ahead. Method: The article is analytical in nature, identifying the different building blocks and relational networks of von Glasersfeld’s two epistemologies. By this, the article intends to contribute to a further advancement of von Glasersfeld’s Epistemology I. Results: The main finding lies in recognizing the radical and innovative elements of von Glasersfeld’s Epistemology I and on the still-challenging research designs of Epistemology I. (shrink)

Volume 2 is made up primarily of unpublished material from the Bradley Papers held at Merton College since Bradley’s death in 1924. The 587 pages of this volume are divided into eight sections with an Introduction by the editor and an Appendix: Introduction by Editor 1. MS Book α : a notebook on metaphysical and psychological topics with Bradley’s index. 2. MS BK T ): one notebook on mainly metaphysical topics with Bradley’s index. 3. Two untitled notebooks containing sketches of (...) chapters for Appearance and Reality. 4. MS BK Z one notebook on psychological topics with Bradley’s index. 5. Draft of a reply to Alfred Sidgwick’s article “Mr. Bradley and the Sceptics” in Mind, vol. 3 ns, July 1894 6. Manuscript of unpublished paper on Alexander Shand’s article “Attention and Will: A Study in Involuntary Action” in Mind, vol. 4 ns, October 1895. 7. Manuscript of unpublished paper on Bertrand Russell’s article “Is Position in Time and Space Absolute or Relative?” in Mind, vol. 10 ns, July 1901. 8. Selections of Bradley’s reading notes on works read from 1883–1902, taken from 5 separate notebooks. Appendix: What Bradley Read. This is a chronological list of works for which there is some positive evidence that Bradley read something from them. The evidence used to determine what he read includes “his correspondence, papers and/or publications”. An acknowledgement of receipt and a promise to read a work is not considered adequate evidence that he actually read the work in question. (shrink)